Aging and the immune system – focus on naïve T-cells
By Vince Giuliano The human immune system provides our defenses against pathogens. This blog entry focuses on research on T-cells. a family of cells in the immune system. The research is relevant to...
View ArticleEditorial – A shift in a key aging sciences paradigm
By Vince Giuliano Mainline scientific theories may have long lifespans but are inevitably overturned as accumulating evidence renders them obsolete and brings alternative theories to the fore. We saw...
View ArticlePhytosubstances – focus on cat’s claw
There is a substantial amount current research on cat’s claw (uncaria tomentosa, in Spanish Uña de Gato), a herb imported from the Peruvian Amazon. This blog entry documents some of the properties of...
View ArticleNot-So-Disposable Somas: Proof of Concept Studies for Increasing Lifespan
By Brendan Hussey In my previous post, The Nuclear DNA Damage/Mutation Theory of Aging, I presented evidence that inequities in cell maintenance between germ and somatic cells are a major causal...
View ArticleProgress update on induced pluripotent stem cells
By Vince Giuliano The last few months have seen the continuation of an extraordinary pace of research related to induced pluripotent stem cells (iPSCs), a technology stream that has been widely...
View ArticleIn-vivo cell reprogramming for longer lives
This blog entry unifies three themes that have repeatedly been expressed in this blog: 1. The possibility of extending lives via using “rebooted” cells, that is induced pluripotent stem cells (iPSCs),...
View ArticleKey roles of glia and microglia in age-related neurodegenerative diseases
Previously I have written about the roles of glia and microglia in Alzheimer’s disease and in spinal cord injury. This blog entry reports on recent research which documents the importance of glial...
View ArticleLatest p16(Ink4a) senescence-reversing research – an important but not...
By Vince Giuliano The press has recently picked up heavily on work by Mayo Clinic researchers related to reversal of cell-senescence in-vivo via inhibition of expression of the protein p16(Ink4a). The...
View ArticleMechanisms and Effects of Dietary Restriction
By Victor In 1934, researchers at Cornell University discovered that laboratory rats fed a severely restricted diet lived up to twice as long as those fed a regular diet. Subsequent research has...
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CAR adoptive stem cell immunotherapy– an emerging new weapon against cancers...
By Vince Giuliano There is current excitement about a new approach to using a person’s own immune system to fight and defeat otherwise incurable cancers: Adoptive immunotherapy, a technology that is...
View ArticleMore about Klotho – spinner of the thread of life
I published an introduction to the remarkable “anti-aging gene” Klotho in the October 2009 blog entryKlotho anti-aging gene in the news, and a September 2010 update Klotho, phosphates, cola drinks and...
View ArticleHistory and future directions for this blog – invitation for associate...
Soon this blog will celebrate its third birthday. So I pause here to discuss where it has been and is going. I also issue a new invitation for applicants who may be interested in becoming associate...
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Focus on phytosubstances – Danshen root – amazing properties of salvia...
Salvia miltiorrhiza Bunge (Danshen root) is an important staple of traditional Chinese medicine that has long been used to treat a variety of illnesses including type-2 diabetes, cardiovascular and...
View ArticleDietary factors and dementia – Part 1: important recent research
By Vince Giuliano This is the first of three blog entries focusing on research during the last two years relating diet, dietary substances and supplements to late-onset dementias including Alzheimer’s...
View ArticleDietary factors and dementia Part 2: possible interventions
By Vince Giuliano The first blog entry in this series of three Dietary factors and dementia – Part 1: important recent research dealt with research on a variety of subtopics such as the value of the...
View ArticleDietary factors and dementia – Part 3: plant-derived substances that can make...
By Vince Giuliano Like the previous two blog entries Dietary factors and dementia – Part 1: important recent researchandDietary factors and dementia Part 2: possible interventions, this blog entry is...
View ArticleAlternate-day Fasting – a better alternative
By Victor For humans who wish to live long lives, alternative-day fasting may be a better approach than following a restricted calorie diet. The approach avoids premature induction of frailty most...
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Circadian Regulation, NMN, Preventing Diabetes, and Longevity
By Victor Circadian Regulation is a fascinating topic with ties to many issues involved in antiaging research, including the regulation of stem cell populations.(See The circadian molecular clock...
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The pivotal role of Nrf2. Part 1 – a new view on the control of oxidative...
The old free radical theory if aging is dead. And, consuming excessive pure antioxidant supplements can be dangerous rather than health producing – see the blog entry End of the free radical theory of...
View ArticleThe pivotal role of Nrf2. Part 2 – foods, phyto-substances and other...
This is the second of three blog entries relating to the Nrf2 pathway. The previous blog entry The pivotal role of Nrf2. Part 1 – a new view on the control of oxidative damage and generation of...
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